Objectives

The main objective of the PERMANENS project is to develop a prototype of a customized Clinical Decision Support System (CDSS) that assists clinicians in the personalized detection, assessment and management of risk for key adverse clinical outcomes among emergency department patients presenting with self-harm

Objectives and methods of the project.

The PERMANENS project’s main objective is to develop a Clinical Decision Support System software prototype that assists clinicians in the personalized detection, assessment and management of risk for key adverse clinical outcomes among emergency department patients presenting with self-harm. The key adverse clinical outcomes PERMANENS aims to tackle include repeat self-harm, method escalation, death by suicide, premature death, and non-compliance with and discontinuation from treatment.

A Clinical Decision Support System that assists clinicians in the personalized detection, assessment and management of risk for key adverse clinical outcomes

Enable the transnational analysis of large amounts of clinical registry data using state-of-the-art data harmonization and federated analysis techniques, in line with national and European data security and privacy regulations
Develop and validate a series of accurate risk prediction models for key adverse outcomes among patients with self-harm, using machine learning-based techniques applied on large amounts of representative registry data
Develop a clinical knowledge base of evidence-based interventions for key adverse outcomes among patients with self-harm, obtained through systematic review and synthesis of both scientific literature and clinical guidelines
Develop a fully functional Clinical Decision Support System software prototype (up to Technology Readiness Level 5) that assists clinicians with accurate risk assessments and with delivering evidence-based care components, in the format of a personalized treatment plan and using a Structured Professional Judgement approach (I.e., not replacing clinical judgement)
Ensure a user-friendly end-product, through implementation research with end-users (i.e., patients and clinicians), including the assessment of unmet treatment needs, and small-scale usability testing outside of routine healthcare

The PERMANENS project is supported by Instituto de Salud Carlos III (ISCIII) and by the European Union NextGenerationEU, Mecanismo para la Recuperación y la Resiliencia (AC22/00006; AC22/00045), the Swedish Innovation Agency (no. 2022-00549), the Research Council of Norway (project no. 342386) and the Health Research Board Ireland (ERAPERMED2022) under the frame of ERA PerMed.